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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD6
All Species:
22.12
Human Site:
S385
Identified Species:
40.56
UniProt:
O43541
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43541
NP_001136333.1
496
53497
S385
E
S
V
R
R
T
R
S
K
I
G
F
G
I
L
Chimpanzee
Pan troglodytes
XP_523105
496
53474
S385
E
S
V
R
R
T
R
S
K
I
G
F
G
I
L
Rhesus Macaque
Macaca mulatta
XP_001104638
454
49165
S343
E
S
V
R
R
T
R
S
K
I
G
F
G
I
L
Dog
Lupus familis
XP_544737
499
53465
S386
E
S
V
R
R
T
R
S
K
I
G
F
G
I
L
Cat
Felis silvestris
Mouse
Mus musculus
O35182
495
53696
S386
E
S
V
R
R
T
R
S
K
I
G
F
G
I
L
Rat
Rattus norvegicus
O88406
426
46439
L323
K
I
G
C
G
I
Q
L
T
R
E
V
D
G
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516238
280
31765
K178
G
Y
G
I
F
L
S
K
E
P
D
G
V
W
A
Chicken
Gallus gallus
Q9W734
431
47806
Y323
R
T
R
S
K
I
G
Y
G
I
L
L
S
K
E
Frog
Xenopus laevis
NP_001091249
352
38824
S250
I
G
L
G
I
V
L
S
R
E
A
D
G
V
W
Zebra Danio
Brachydanio rerio
Q9I9P9
468
52435
R331
A
T
V
E
M
T
R
R
H
I
G
R
G
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
I343
E
C
L
S
D
S
A
I
F
V
Q
S
R
N
C
Honey Bee
Apis mellifera
XP_396816
251
28007
A149
Q
E
A
D
G
V
W
A
Y
N
R
S
E
S
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798238
371
42051
S269
I
D
Y
G
L
S
M
S
R
E
E
D
G
V
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
90.7
94.9
N.A.
93.3
42.5
N.A.
44.3
67.5
51
23.7
N.A.
22.5
29.2
N.A.
38.9
Protein Similarity:
100
99.4
90.9
95.7
N.A.
94.3
54.2
N.A.
49.7
73.1
58
39.9
N.A.
38.9
34.4
N.A.
50.2
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
0
6.6
13.3
40
N.A.
6.6
0
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
6.6
20
33.3
53.3
N.A.
26.6
13.3
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
0
8
8
0
0
8
0
0
0
8
% A
% Cys:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
8
0
8
8
0
0
0
0
0
8
16
8
0
0
% D
% Glu:
47
8
0
8
0
0
0
0
8
16
16
0
8
0
8
% E
% Phe:
0
0
0
0
8
0
0
0
8
0
0
39
0
0
0
% F
% Gly:
8
8
16
16
16
0
8
0
8
0
47
8
62
8
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
16
8
0
8
8
16
0
8
0
54
0
0
0
39
0
% I
% Lys:
8
0
0
0
8
0
0
8
39
0
0
0
0
8
0
% K
% Leu:
0
0
16
0
8
8
8
8
0
0
8
8
0
0
39
% L
% Met:
0
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% P
% Gln:
8
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% Q
% Arg:
8
0
8
39
39
0
47
8
16
8
8
8
8
0
8
% R
% Ser:
0
39
0
16
0
16
8
54
0
0
0
16
8
8
0
% S
% Thr:
0
16
0
0
0
47
0
0
8
0
0
0
0
0
0
% T
% Val:
0
0
47
0
0
16
0
0
0
8
0
8
8
24
8
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
16
% W
% Tyr:
0
8
8
0
0
0
0
8
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _